Alphafold3. Quo vadis?

AlphaFold3 represents a significant leap in the field of computational biology with its ability to predict 3D protein structures. However, its predictive power remains limited when it comes to protein-DNA complexes. While AlphaFold3 excels at modelling individual protein structures with high accuracy, the intricate interactions between proteins and DNA introduce a level of complexity that the current algorithms struggle to capture. Consequently, predictions for protein-DNA structures often lack the precision required for detailed functional insights. Despite these limitations, AlphaFold3 remains a valuable tool for generating hypotheses and guiding experimental validation in structural biology.

Alphafold3 prediction